Endocrine Abstracts

Hyperthyroidism is associated with increased thrombotic risk through mechanisms that are not fully understood. In contrast, a tendency to bleeding has been reported in hypothyroidism. Fibrin network structure has been shown to determine susceptibility to atherothrombosis and venous thrombotic events and therefore, this study investigates the effects of thyroid-dysfunction on clot structure and fibrinolysis using longitudinal interventional studies.Sevent...

Objective: Tumors of the pituitary gland and sellar region, called pitiutary adenoma (PA) represent approximatly 10% of all central nervous system tumors. The characteristics of these tumors may vary from population to population.Aim: The aim of this retrospective study was to investigate and understand the clinicopathological characteristics, the invasiveness, tumor features and clinical symptoms of PA in adult patients at south great plain region of Hu...

Background: Despite obligatory iodination of salt in the Czech Republic, pregnant women with higher demands on iodine intake may be at risk of iodine deficiency with potentially negative consequences for the course of pregnancy and foetal development. Determination of urinary iodine concentration (UIC) is a conventional but not widely available method used to estimate the iodine status. Based on previous studies, serum thyroglobulin (Tg) could serve as a more convenient marker...

Age-related cognitive decline in postmenopausal women is thought to be partially related to the loss of sex steroids. Like women, old female rhesus monkeys (Macaca mulatta) undergo menopause and show an associated decline in circulating estradiol levels. Similarly, they show an age-related decline in the release of dehydroepiandrosterone (DHEA) from their adrenal glands. Because DHEA acts as a substrate for estradiol synthesis in the brain, it is plausible that DHEA sup...

Introduction: The incidence of adrenal incidentaloma (AI) increases with age. According to epidemiological studies they are more frequent in women than in men.Aim: The aim was to determine the possible clinical sexual dimorphism in patients with nonfunctional adrenal incidentaloma (NAI).Patients and methods: This was an observational, cross-sectional study of 381 patients with AI that were functionally assessed in our Clinic. After...

Introduction: Many diseases of the adrenal cortex show a higher prevalence in women than men with incidence increasing with age in both genders.Aim: The aim was to determine the possible sexual dimorphism in patients with adrenal incidentaloma (AI) and (possible) autonomous cortisol secretion ((P)ACS).Methods: This was an observational, cross-sectional study of 381 patients with AI that were functionally assessed in our Clinic. Aft...

Background: Reproductive health is a state of complete physical, mental, and social well-being. So far, there is limited evidence about the consequences of Sars-CoV-2 infection on women’s reproductive health.Aim: To determine the effects of Sars-CoV-2 infection on women’s reproductive health.Methods: We created an anonymous survey about reproductive health and shared it with women of reproductive age between May 2022 and ...

Introduction: Relative adrenal insufficiency (RAI) is common in critically ill patients and is characterized by the normal adrenal reserve for homeostatic demands and inadequate cortisol response in acute stress situations. RAI can also occur in patients with liver cirrhosis, both compensated and decompensated. However, it is often forgotten and difficult to diagnose due to the overlap between clinical symptoms of adrenal insufficiency and decompensated liver disease. Also, hy...

Significant knowledge gaps exist regarding the humanistic effects of hypoparathyroidism, a rare, debilitating disorder. We report results from a global survey to characterise the burden of hypoparathyroidism from the patient perspective. An anonymous survey was conducted in patients with uncontrolled chronic hypoparathyroidism (as determined by patients’ report of persistent symptoms and/or poorly controlled calcium levels as told by their physician) despite receiving con...

Background: Prior small studies have suggested increased risk of cardiovascular (CV) conditions in patients with hypoparathyroidism (HypoPT). We evaluated whether chronic HypoPT is associated with increased risk of select CV hard endpoints (i.e., myocardial infarction (MI), stroke, and a composite CV endpoint) in a large contemporary cohort.Methods: A retrospective cohort study, based on a US commercial claims database (Q1 2007 - Q2 2017), was conducted ...